|
Symbol Name ID |
Il18
interleukin 18 MGI:107936 |
| Darker colors indicate more annotations |
| Human Phenotypes | Recurrent pharyngitis |
Allergic rhinitis |
Conjunctivitis |
Pericarditis |
Mediastinal lymphadenopathy |
Splenomegaly |
Subacute progressive viral hepatitis |
Iridocyclitis |
Epididymitis |
Eczematoid dermatitis |
Atopic dermatitis |
Erythema nodosum |
Recurrent skin infections |
Autoimmunity |
Asthma |
Meningitis |
| Disease(s) Associated with IL18 | ||||||||||||||||
| alopecia areata | ||||||||||||||||
| asthma | ||||||||||||||||
| atopic dermatitis | ||||||||||||||||
| Behcet's disease | ||||||||||||||||
| biliary atresia | ||||||||||||||||
| hepatocellular carcinoma | ||||||||||||||||
| temporal arteritis |
| Mouse Phenotypes | impaired neutrophil chemotaxis |
increased susceptibility to induced colitis |
stomach inflammation |
enlarged spleen |
increased neutrophil cell number |
increased dendritic cell number |
increased NK cell number |
decreased T cell number |
increased macrophage cell number |
abnormal T cell morphology |
abnormal microglial cell morphology |
abnormal spleen morphology |
increased IgE level |
increased IgG1 level |
impaired natural killer cell mediated cytotoxicity |
abnormal T cell physiology |
abnormal T-helper 1 physiology |
abnormal macrophage physiology |
decreased circulating interferon-gamma level |
decreased circulating interleukin-18 level |
increased circulating interleukin-18 level |
decreased circulating interleukin-6 level |
increased circulating tumor necrosis factor level |
abnormal cytokine level |
abnormal interferon level |
abnormal interleukin level |
abnormal tumor necrosis factor level |
decreased interferon-gamma secretion |
increased interferon-gamma secretion |
increased interleukin-13 secretion |
decreased tumor necrosis factor secretion |
decreased susceptibility to endotoxin shock |
lung inflammation |
interstitial pneumonia |
dermatitis |
decreased susceptibility to bacterial infection |
increased susceptibility to bacterial infection |
increased susceptibility to parasitic infection |
sepsis |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||
| Il18tm1Aki/Il18tm1Aki | ||||||||||||||||||||||||||||||||||||||||
| Il18tm1Khe/Il18tm1Khe | ||||||||||||||||||||||||||||||||||||||||
| Il18tm1Liew/Il18tm1Liew | ||||||||||||||||||||||||||||||||||||||||
| Tg(KRT14-Il18)#Knak/0 | ||||||||||||||||||||||||||||||||||||||||
| Tg(SFTPC-Il18)AThos/0 | ||||||||||||||||||||||||||||||||||||||||
| Tg(CAG-cat,-Il18)#Thos/0 Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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